Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry

  title={Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry},
  author={H. Yoshioka and C. Meno and K. Koshiba and Minoru Sugihara and H. Itoh and Y. Ishimaru and T. Inoue and H. Ohuchi and E. Semina and J. C. Murray and H. Hamada and S. Noji},
  • H. Yoshioka, C. Meno, +9 authors S. Noji
  • Published 1998
  • Biology, Medicine
  • Cell
  • Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid-type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in… CONTINUE READING
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