Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb.

@article{Delaurier2006Pitx1DT,
  title={Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb.},
  author={April Delaurier and Ronen Schweitzer and Malcolm Logan},
  journal={Developmental biology},
  year={2006},
  volume={299 1},
  pages={22-34}
}
The vertebrate forelimb and hindlimb are serially homologous structures; however, their distinctive morphologies suggest that different mechanisms are associated with each limb type to give rise to limb-type identity. Three genes have been implicated in this process; T-box transcription factors Tbx5 and Tbx4, which are expressed in the forelimb and hindlimb, respectively, and a paired-type homeodomain transcription factor Pitx1, expressed in the hindlimb. To explore the roles of Pitx1 and Tbx4… CONTINUE READING

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