Pituitary volume, stress reactivity and genetic risk for psychotic disorder.

  title={Pituitary volume, stress reactivity and genetic risk for psychotic disorder.},
  author={P. J. J. H. A. Habets and Dina Collip and Inez Myin-Germeys and E. H. B. M. Gronenschild and Suzanne C van Bronswijk and P. Hofman and Tineke Lataster and Mari{\"e}lle Lardinois and Nancy A Nicolson and Jim van Os and Machteld Marcelis},
  journal={Psychological medicine},
  volume={42 7},
BACKGROUND Hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, associated with increased pituitary volume, may mediate observed alterations in stress reactivity in patients with psychotic disorder. We examined the association between pituitary volume, real-life stress reactivity and genetic liability for psychotic disorder. METHOD Pituitary volumes were derived from magnetic resonance imaging (MRI) scans of 20 patients with psychotic disorder, 37 non-psychotic siblings of these patients… CONTINUE READING