Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer.

@article{Kim2006PituitaryTG,
  title={Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer.},
  author={D S Kim and Jayne A. Franklyn and Anna L. Stratford and Kristien Boelaert and John C. Watkinson and Margaret C. Eggo and Christopher J McCabe},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 3},
  pages={1119-28}
}
CONTEXT Pituitary tumor-transforming gene (PTTG) is a multifunctional protein involved in several tumorigenic mechanisms, including angiogenesis. PTTG has been shown to promote angiogenesis, a key rate-limiting step in tumor progression, by up-regulation of fibroblast growth factor-2 and vascular endothelial growth factor. OBJECTIVE To investigate whether PTTG regulates other angiogenic genes in thyroid cells, we performed angiogenesis-specific cDNA arrays after PTTG transfection. Two of the… CONTINUE READING