Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis.

@article{Yin2008PituitaryspecificKO,
  title={Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis.},
  author={Zhirong Yin and Lisa Williams-Simons and Albert F. Parlow and Sylvia W Asa and Lawrence S. Kirschner},
  journal={Molecular endocrinology},
  year={2008},
  volume={22 2},
  pages={380-7}
}
Carney complex (CNC) is an inherited neoplasia syndrome characterized by spotty skin pigmentation, myxomas, endocrine tumors, and schwannomas. Among the endocrine tumors that comprise the syndrome, GH-producing pituitary tumors are seen in approximately 10% of patients, although biochemical abnormalities of the GH axis are much more common. To explore the role of loss of the CNC gene PRKAR1A on pituitary tumorigenesis, we produced a tissue-specific knockout (KO) of this gene in the mouse. For… CONTINUE READING
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