Pituitary sensitizing effect of GnRH antagonists: a mechanism explaining LH escape during IVF?

@article{Banga2010PituitarySE,
  title={Pituitary sensitizing effect of GnRH antagonists: a mechanism explaining LH escape during IVF?},
  author={Franyke R Banga and Judith Af Huirne and Ted J M Korsen and Roy Homburg and Peter G. A. Hompes and Cornelius B Lambalk},
  journal={Human reproduction},
  year={2010},
  volume={25 6},
  pages={1513-9}
}
BACKGROUND GnRH antagonists have been introduced to induce persistent LH suppression. Many studies show a gradual increase of LH levels after several days of GnRH antagonist administration, the so-called escape or rebound effect. We hypothesize that, under chronic GnRH antagonist administration, a higher pituitary response to GnRH could be an underlying mechanism explaining the escape phenomenon. METHODS In a prospective study, pituitary response to a supramaximal test dose of GnRH was tested… CONTINUE READING