Pituitary senescence: the evolving role of Pttg.

  title={Pituitary senescence: the evolving role of Pttg.},
  author={Vera Chesnokova and Shlomo Melmed},
  journal={Molecular and cellular endocrinology},
  volume={326 1-2},
Despite the high prevalence of pituitary adenomas they are invariably benign, indicative of unique intrinsic mechanisms controlling pituitary cell proliferation. Cellular senescence is characterized by a largely irreversible cell cycle arrest and constitutes a strong anti-proliferative response, which can be triggered by DNA damage, chromosomal instability and aneuploidy, loss of tumor suppressive signaling or oncogene activation. In vivo senescence is an important protective mechanism against… CONTINUE READING


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