Pituitary lactotrope expresses transforming growth factor β (TGFβ) type II receptor mRNA and protein and contains 125I-TGFβ1 binding sites

@inproceedings{De1996PituitaryLE,
  title={Pituitary lactotrope expresses transforming growth factor β (TGFβ) type II receptor mRNA and protein and contains 125I-TGFβ1 binding sites},
  author={Alok De and Todd E. Morgan and Robert C Speth and Nadka I. Boyadjieva and Dipak K Sarkar},
  year={1996}
}
Transforming growth factor β1 (TGF β1) has recently been shown to be produced in the prolactin (PRL)-secreting lactotropes of the pituitary gland. TGFβ1 inhibits lactotropic secretion and proliferation, and the production of TGFβ1 in lactotropes is reduced during lactotropic growth following estrogen treatment in ovariectomized rats. In many estrogen-responsive tissues, TGFβ1 has been shown to exert its effect by binding to TGFβ1 type II receptors (TβR II) at the cell surface. In this study, we… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Intercellular communication in the anterior pituitary.

  • Endocrine reviews
  • 2000
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED