Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1

@article{Lee2013PituitaryH2,
  title={Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1},
  author={Wing-Kee Lee and P. Chakraborty and F. Th{\'e}venod},
  journal={International Journal of Cancer},
  year={2013},
  volume={133}
}
  • Wing-Kee Lee, P. Chakraborty, F. Thévenod
  • Published 2013
  • Biology, Medicine
  • International Journal of Cancer
    • The multidrug resistance (MDR) P‐glycoprotein ABCB1 plays a major role in MDR of malignant cells and is regulated by various transcription factors, including Wnt/β‐catenin/TCF4. The transcription factor PITX2 (Pituitary homeobox‐2) is essential for embryonic development. PITX2 operates by recruiting and interacting with β‐catenin to increase the expression of growth‐regulating genes, such as cyclin D1/2 and c‐Myc. The importance of PITX2 in malignancy is not yet known. Here we demonstrate that… CONTINUE READING
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    21 Citations
    Background Citations
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    Methods Citations
    1
    21 Citations
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    Citation Type

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