Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1

@article{Lee2013PituitaryH2,
  title={Pituitary homeobox 2 (PITX2) protects renal cancer cell lines against doxorubicin toxicity by transcriptional activation of the multidrug transporter ABCB1},
  author={Wing-Kee Lee and P. Chakraborty and F. Th{\'e}venod},
  journal={International Journal of Cancer},
  year={2013},
  volume={133}
}
  • Wing-Kee Lee, P. Chakraborty, F. Thévenod
  • Published 2013
  • Biology, Medicine
  • International Journal of Cancer
  • The multidrug resistance (MDR) P‐glycoprotein ABCB1 plays a major role in MDR of malignant cells and is regulated by various transcription factors, including Wnt/β‐catenin/TCF4. The transcription factor PITX2 (Pituitary homeobox‐2) is essential for embryonic development. PITX2 operates by recruiting and interacting with β‐catenin to increase the expression of growth‐regulating genes, such as cyclin D1/2 and c‐Myc. The importance of PITX2 in malignancy is not yet known. Here we demonstrate that… CONTINUE READING
    21 Citations
    Upregulation of PITX2 Promotes Letrozole Resistance Via Transcriptional Activation of IFITM1 Signaling in Breast Cancer Cells
    • Yingying Xu, H. Yu, +8 authors Q. Zhang
    • Medicine
    • Cancer research and treatment : official journal of Korean Cancer Association
    • 2019
    • 4
    • PDF
    Histone deacetylase 2 regulates doxorubicin (Dox) sensitivity of colorectal cancer cells by targeting ABCB1 transcription
    • 19
    HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells
    • 29
    • PDF
    Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?
    • 19
    PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex.
    • 10

    References

    SHOWING 1-10 OF 60 REFERENCES
    Pituitary homeobox 2 (PITX2) promotes thyroid carcinogenesis by activation of cyclin D2
    • 36
    • Highly Influential
    Increased Expression of PITX2 Transcription Factor Contributes to Ovarian Cancer Progression
    • 34
    • PDF
    The Significance of PITX2 Overexpression in Human Colorectal Cancer
    • 31
    Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway
    • 147
    • Highly Influential
    • PDF