Pituitary gonadotropin-independent male-limited autosomal dominant sexual precocity in nine generations: familial testotoxicosis.

@article{Egli1985PituitaryGM,
  title={Pituitary gonadotropin-independent male-limited autosomal dominant sexual precocity in nine generations: familial testotoxicosis.},
  author={Christine Egli and Stephen M. Rosenthal and Melvin M Grumbach and J M Montalvo and Bernard Gondos},
  journal={The Journal of pediatrics},
  year={1985},
  volume={106 1},
  pages={
          33-40
        }
}
A recently described, distinct form of male sexual precocity is characterized by premature Leydig and germinal cell maturation in the absence of pituitary gonadotropin stimulation. Analysis of a nine-generation kindred with at least 28 affected males supports sex-limited autosomal dominant transmission. Three boys, with precocious sexual development at 1 to 4 years of age, had low basal plasma gonadotropin values without pubertal-type pulsatility and a minimal rise in luteinizing hormone after… CONTINUE READING