Pituitary-gonadal function in neonatal and adult female rats treated with gonadotropin-releasing hormone agonist and antagonist: short- and long-term effects.

@article{Trimio1993PituitarygonadalFI,
  title={Pituitary-gonadal function in neonatal and adult female rats treated with gonadotropin-releasing hormone agonist and antagonist: short- and long-term effects.},
  author={E Trimi{\~n}o and Leonor Pinilla and Enrique Aguilar},
  journal={Acta endocrinologica},
  year={1993},
  volume={129 3},
  pages={251-9}
}
We have analyzed the mechanisms involved in ovarian failure after administration of gonadotropin hormone-releasing hormone agonists (GnRH-A) or antagonists (GnRH-ANT). Ovarian and uterine weights, serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol and pituitary FSH and LH contents were measured in Wistar female rats injected from 1-15 or 90-104 days of age with the agonist D-Ala6-D-Gly10-GnRH or the GnRH-ANT Org. 30276. Vaginal opening, first… CONTINUE READING