Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats.

@article{Li1992PituitaryEC,
  title={Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats.},
  author={Ying Li and D L Brunke and Robert Dantzer and Keith W. Kelley},
  journal={Endocrinology},
  year={1992},
  volume={130 5},
  pages={2703-9}
}
Although implantation of GH3 pituitary epithelial cells has been shown to reverse thymic aging in rats, the differentiation pattern of T-lymphocytes within the reconstituted thymus glands has not been investigated. Syngeneic GH3 cells were implanted into 22-month-old female (old) Wistar-Furth rats. Eight weeks later, thymus glands and thymocyte subpopulations were compared to those in aged (24-month-old) and young (3-month-old) female Wistar Furth rats. We confirmed that implantation of GH3… CONTINUE READING

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