Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts.

@article{Akita1997PituitarydirectedLI,
  title={Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts.},
  author={Sachiko Akita and Carol Readhead and Lucia Stefaneanu and Jason Fine and A Tampanaru-Sarmesiu and K{\'a}lm{\'a}n Kov{\'a}cs and Shlomo Melmed},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 10},
  pages={2462-9}
}
Leukemia inhibitory factor (LIF) and LIF receptors are expressed in adenohypophyseal cells and LIF regulates pituitary hormone transcription and cell replication in vitro. Therefore, transgenic mice expressing pituitary-directed LIF driven by the rat growth hormone (GH) promoter were generated to evaluate the impact of LIF on pituitary development. Three founders were established with diminished linear growth and body weight (57-65% of wild type [WT]), and intense anterior pituitary LIF… CONTINUE READING
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Rathke’s cleft cyst: not such a benign lesion

  • J. J. Mukherjee, N. Islam, +7 authors A. B. Grossman
  • J. Endocrinol
  • 1996

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