Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood.

Abstract

CONTEXT Evidence suggests that early adverse experiences play a preeminent role in development of mood and anxiety disorders and that corticotropin-releasing factor (CRF) systems may mediate this association. OBJECTIVE To determine whether early-life stress results in a persistent sensitization of the hypothalamic-pituitary-adrenal axis to mild stress in… (More)

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