Pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the GTPase RhoA.

@article{Meyer2005PituitaryAC,
  title={Pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the GTPase RhoA.},
  author={Dieter K. Meyer and Catharina Fischer and Ulrike Becker and Isabel G{\"o}ttsching and St{\'e}phanie Boutillier and Christian Baermann and Gudula Schmidt and Norbert Klugbauer and Jost Leemhuis},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 26},
  pages={25258-66}
}
Pituitary adenylyl cyclase-activating polypeptide 38 (PACAP38) plays an important role in the proliferation and differentiation of neural cells. In the present study, we have investigated how PACAP38 inhibits the proliferation of cultured neocortical astroglial cells. When applied to synchronized cells during the G(1) phase of the cell cycle, PACAP38 diminished the subsequent nuclear uptake of bromodeoxyuridine. When applied for 2 days, it reduced the cell number. PACAP38 did not exert its… CONTINUE READING