Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.

@article{Yada1994PituitaryAC,
  title={Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.},
  author={Toshikazu Yada and Mikiko Sakurada and Kaori Ihida and Masaya Nakata and Fusayoshi Murata and Tsunetoshi Honma and Miki Kikuchi},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 2},
  pages={
          1290-3
        }
}
Insulin secretion from pancreatic islets is controlled by peptides as well as by nutrients. We report here a novel, extraordinarily potent peptidergic regulation of insulin secretion. A 27-residue form of pituitary adenylate cyclase activating polypeptide (PACAP27) as low as 10(-14) to 10(-13) M stimulated insulin release from rat islets in a glucose-dependent manner. PACAP27 also increased cytosolic free Ca2+ concentration ([Ca2+]i) in islet beta-cells. Nitrendipine, a blocker of the L-type… CONTINUE READING

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