Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide inhibit feeding in the chick brain by different mechanisms.

@article{Tachibana2003PituitaryAC,
  title={Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide inhibit feeding in the chick brain by different mechanisms.},
  author={Tetsuya Tachibana and Shozo Tomonaga and Daichi Oikawa and Shin Saito and Tomo Takagi and Ei-suke Saito and Tim Boswell and Mitsuhiro Furuse},
  journal={Neuroscience letters},
  year={2003},
  volume={348 1},
  pages={25-8}
}
Intracerebroventricular (ICV) injections of pituitary adenylate cyclase-activating polypeptide-38 (PACAP) and vasoactive intestinal peptide (VIP) inhibit feeding in chicks. However, the precise anorexigenic mechanisms have not been investigated, since both peptides activate the VPAC receptor in mammals. We investigated which receptor mediates the anorexigenic effects of these peptides in chicks. ICV co-injection of PACAP (6-38), a PAC1 receptor antagonist, attenuated the anorexigenic effect of… CONTINUE READING

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