Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) has been reported to decrease ischemic neuronal damage and increase IL-6 secretion in rats. However, the mechanisms underlying neuroprotection are still to be fully elucidated. The present study was designed to investigate the role played by PACAP and IL-6 in mediating neuroprotection after ischemia… (More)

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Cite this paper

@article{Ohtaki2006PituitaryAC, title={Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.}, author={Hirokazu Ohtaki and Tomoya Nakamachi and Kenji Dohi and Yoichi Aizawa and Atsushi Takaki and Kei Hodoyama and Sachiko Yofu and Hitoshi Hashimoto and Norihito Shintani and Akemichi Baba and Manfred Kopf and Yoichiro Iwakura and Kouhei Matsuda and Akira Arimura and Seiji Shioda}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2006}, volume={103 19}, pages={7488-93} }