Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity.

@article{Morio1996PituitaryAC,
  title={Pituitary adenylate cyclase-activating polypeptide protects rat-cultured cortical neurons from glutamate-induced cytotoxicity.},
  author={Hiroshi Morio and Ichiro Tatsuno and Akiko Hirai and Yutaka Tamura and Yasushi Saito},
  journal={Brain research},
  year={1996},
  volume={741 1-2},
  pages={82-8}
}
We have investigated the effects of pituitary adenylate cyclase-activating polypeptide with 38 residues (PACAP38) on glutamate-induced neuronal cell death in rat-cultured cortical neurons. The rat-cultured neurons were obtained from E17 day-old embryos and cultured in a chemically defined medium without serum for 10 days, after which more than 95% of the cells were stained by a specific antibody against MAP-2, a specific marker for neurons. The number of viable neurons was identified by the… CONTINUE READING

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