Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.

@article{Mabuchi2004PituitaryAC,
  title={Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.},
  author={Tamaki Mabuchi and Norihito Shintani and Shinji Matsumura and Emiko Okuda-Ashitaka and Hitoshi Hashimoto and Tadatoshi Muratani and Toshiaki Minami and A. Ramesha Baba and Seiji Ito},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 33},
  pages={7283-91}
}
The prolonged sensitization of pain transmission after nerve injury by increasing excitability of spinal neurons and thereby promoting repair is an adaptive response of the body. The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in the nervous system and implicated in neurotransmission, neural plasticity, and neurotrophic actions. Although PACAP is distributed in the spinal cord and dorsal root ganglia, a role of PACAP in pain responses remains… CONTINUE READING
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