Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity.

@article{Han2014PituitaryAC,
  title={Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity.},
  author={Pengcheng Han and Zhiwei Tang and Junxiang Yin and Marwan Maalouf and Thomas Gerald Beach and Eric M. Reiman and Jiong Shi},
  journal={Neurobiology of aging},
  year={2014},
  volume={35 9},
  pages={2064-71}
}
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP expression in postmortem human AD and triple transgenic mouse (3xTG, Psen1/APPSwe/TauP301L) brains. We established an in vitro model of primary neuronal cell culture to study the protective effects of PACAP against β-amyloid (Aβ) toxicity. We further studied the PACAP-Sirtuin 3 (Sirt3) pathway on mitochondrial function. PACAP… CONTINUE READING

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