Pituitary adenylate cyclase activating polypeptide in stress-related disorders: data convergence from animal and human studies.

@article{Hammack2015PituitaryAC,
  title={Pituitary adenylate cyclase activating polypeptide in stress-related disorders: data convergence from animal and human studies.},
  author={Sayamwong E. Hammack and Victor May},
  journal={Biological psychiatry},
  year={2015},
  volume={78 3},
  pages={167-77}
}
The maladaptive expression and function of several stress-associated hormones have been implicated in pathological stress and anxiety-related disorders. Among these, recent evidence has suggested that pituitary adenylate cyclase activating polypeptide (PACAP) has critical roles in central neurocircuits mediating stress-related emotional behaviors. We describe the PACAPergic systems, the data implicating PACAP in stress biology, and how altered PACAP expression and signaling may result in… CONTINUE READING
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