Pituitary adenylate cyclase activating polypeptide: an important vascular regulator in human skin in vivo.

@article{Seeliger2010PituitaryAC,
  title={Pituitary adenylate cyclase activating polypeptide: an important vascular regulator in human skin in vivo.},
  author={Stephan Seeliger and Joerg Buddenkotte and Anjona Schmidt-Choudhury and Carine Rosignoli and Victoria Shpacovitch and U von Arnim and Dieter Metze and Roman R Rukwied and Martin Schmelz and Ralf Paus and Johannes J. Voegel and Wolfgang Schmidt and Martin S Steinhoff},
  journal={The American journal of pathology},
  year={2010},
  volume={177 5},
  pages={2563-75}
}
Pituitary adenylate cyclase-activating peptide (PACAP) is an important neuropeptide and immunomodulator in various tissues. Although this peptide and its receptors (ie, VPAC1R, VPAC2R, and PAC1R) are expressed in human skin, their biological roles are unknown. Therefore, we tested whether PACAP regulates vascular responses in human skin in vivo. When injected intravenously, PACAP induced a significant, concentration-dependent vascular response (ie, flush, erythema, edema) and mediated a… CONTINUE READING

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