Pituitary adenylate cyclase-activating peptide enhances electrical coupling in the mouse adrenal medulla.

Abstract

Neuroendocrine adrenal medullary chromaffin cells receive synaptic excitation through the sympathetic splanchnic nerve to elicit catecholamine release into the circulation. Under basal sympathetic tone, splanchnic-released acetylcholine evokes chromaffin cells to fire action potentials, leading to synchronous phasic catecholamine release. Under elevated… (More)
DOI: 10.1152/ajpcell.00119.2012

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