Pituitary adenylate cyclase-activating peptide as a neurotransmitter in the canine ileal circular muscle.

Abstract

Pituitary adenylate cyclase-activating peptide (PACAP)1-27, PACAP1-38, and vasoactive intestinal peptide (VIP) initiated dose-dependent contractions of canine ileal circular muscle after intra-arterial injection in vivo or ex vivo. PACAP1-27- and VIP-induced contractions approached the tissue maximum; VIP was 100-fold less potent. PACAP1-38 was more potent… (More)

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@article{FoxThrelkeld1999PituitaryAC, title={Pituitary adenylate cyclase-activating peptide as a neurotransmitter in the canine ileal circular muscle.}, author={J A Fox-Threlkeld and Tony McDonald and Zofia Woskowska and Keigo Iesaki and Ebenezer Daniel}, journal={The Journal of pharmacology and experimental therapeutics}, year={1999}, volume={290 1}, pages={66-75} }