Pituitary adenomas in acromegalic patients: an immunohistochemical and endocrinological study with special reference to prolactin-secreting adenoma.

@article{Kanie1983PituitaryAI,
  title={Pituitary adenomas in acromegalic patients: an immunohistochemical and endocrinological study with special reference to prolactin-secreting adenoma.},
  author={N Kanie and Naoki Kageyama and Akio Kuwayama and Tokio Nakane and Mika Watanabe and Akira Kawaoi},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1983},
  volume={57 6},
  pages={1093-101}
}
To establish a functional classification of purification of pituitary adenomas in acromegalic patients, we used immunoperoxidase-staining techniques specific for GH and PRL. Surgical specimens from 55 acromegalic patients were studied. GH was demonstrated in all adenomas and PRL was found in 25 of them (45.5%). Immunohistologically, GH- and PRL-containing adenomas could be divided into 3 types. In type 1 (11 patients), immunoreactive PRL was present in single cells surrounded by immunoreactive… CONTINUE READING