Pituitary-Specific Overexpression of Porcine Follicle-Stimulating Hormone Leads to Improvement of Female Fecundity in BAC Transgenic Mice

@inproceedings{Bi2012PituitarySpecificOO,
  title={Pituitary-Specific Overexpression of Porcine Follicle-Stimulating Hormone Leads to Improvement of Female Fecundity in BAC Transgenic Mice},
  author={Ming Jun Bi and Jia Tong and Fei Chang and Jing Wang and Hengxi Wei and Yunping Dai and Ming-Xing Chu and Yaofeng Zhao and Ning Li},
  booktitle={PloS one},
  year={2012}
}
Follicle-stimulating hormone (FSH) is a pituitary glycoprotein that, together with luteinizing hormone, plays a crucial role in ovarian folliculogenesis and female fertility. We previously found that FSH beta is a major gene controlling high prolificacy of Chinese Erhualian pigs. To directly study the biological effects on reproductive function of porcine FSH (pFSH) for polyovulatory species, we generated a novel gain-of-function mouse model using a bacterial artificial chromosome (BAC) system… CONTINUE READING