Pituitary Changes in Prop1 Transgenic Mice: Hormone Producing Tumors and Signet-ring Type Gonadotropes

@article{Egashira2008PituitaryCI,
  title={Pituitary Changes in Prop1 Transgenic Mice: Hormone Producing Tumors and Signet-ring Type Gonadotropes},
  author={Noboru Egashira and Takeo Minematsu and Syunsuke Miyai and Susumu Takekoshi and Sally A Camper and Robert Yoshiyuki Osamura},
  journal={Acta Histochemica et Cytochemica},
  year={2008},
  volume={41},
  pages={47 - 57}
}
Prophet of Pit-1 (Prop1) is an early transcription factor that delays the appearance of gonadotropin in the developing pituitaries. Prop1 transgenic (Tg) mice have been shown to generate pituitary tumors that either produce TSH or are non-hormone producing. In our series of Prop1 Tg mice, only 5 out of 9 female mice produced pituitary adenomas, and the adenomas were only GH, PRL, GH and PRL, PRL and gonadotropin or TSH producing. The pituitary cells that surrounded these adenomas showed… CONTINUE READING

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Pit-1 gene inhibition using small interfering RNAs in rat pituitary GH secreting cell line

  • S. Miyai, J. Itoh, H. Kajiya, S. Takekoshi, R. Y. Osamura
  • Acta Histochem. Cytochem
  • 2005
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