Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Glucose Production via the Hepatic Sympathetic Innervation in Rats

@inproceedings{Yi2010PituitaryAC,
  title={Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Glucose Production via the Hepatic Sympathetic Innervation in Rats},
  author={Chun-xia Yi and Ning Sun and Mariette T Ackermans and Anneke Alkemade and Ewout Foppen and Jing Shi and Mireille J Serlie and Ruud Marinus Buijs and Eric Fliers and Andries Kalsbeek},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE The unraveling of the elaborate brain networks that control glucose metabolism presents one of the current challenges in diabetes research. Within the central nervous system, the hypothalamus is regarded as the key brain area to regulate energy homeostasis. The aim of the present study was to investigate the hypothalamic mechanism involved in the hyperglycemic effects of the neuropeptide pituitary adenylyl cyclase-activating polypeptide (PACAP). RESEARCH DESIGN AND METHODS… CONTINUE READING

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