Pitfalls on the roadmap to gammadelta T cell-based cancer immunotherapies.

@article{Martinet2009PitfallsOT,
  title={Pitfalls on the roadmap to gammadelta T cell-based cancer immunotherapies.},
  author={Ludovic Martinet and R{\'e}my Poupot and Jean-Jacques Fourni{\'e}},
  journal={Immunology letters},
  year={2009},
  volume={124 1},
  pages={1-8}
}
Human TCRVgamma9Vdelta2+ gammadelta cells are unconventional T lymphocytes which had not been specifically mobilized in any cancer vaccine or immunotherapy so far, although they present the major advantage of mediating an HLA-unrestricted highly cytotoxic activity directed against most human tumor cell types. The rapid development of highly selective small molecule agonists targeting these lymphocytes has recently paved the way to clinical trials assessing their activity against cancer. Despite… CONTINUE READING

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