Pitfalls in fMRI

@article{Haller2009PitfallsIF,
  title={Pitfalls in fMRI},
  author={Sven Haller and Andreas J. Bartsch},
  journal={European Radiology},
  year={2009},
  volume={19},
  pages={2689-2706}
}
Several different techniques allow a functional assessment of neuronal activations by magnetic resonance imaging (fMRI). The by far most influential fMRI technique is based on a local T2*-sensitive hemodynamic response to neuronal activation, also known as the blood oxygenation level dependent or BOLD effect. Consequently, the term ‘fMRI’ is often used synonymously with BOLD imaging. Because interpretations of fMRI brain activation maps often appear intuitive and compelling, the reader might be… 

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References

SHOWING 1-10 OF 168 REFERENCES
Mapping continuous neuronal activation without an ON–OFF paradigm: initial results of BOLD ceiling fMRI
TLDR
BOLD ceiling fMRI is proposed as a complement to standard fMRI for those conditions where ON–OFF paradigms are impossible and hypothesize that active areas exhibit a reduced CO2‐induced ΔBOLD due to pre‐existing ‘local’ task‐induced BOLD response.
What we can do and what we cannot do with fMRI
TLDR
An overview of the current state of fMRI is given, and the current understanding of the haemodynamic signals and the constraints they impose on neuroimaging data interpretation are presented.
Neurophysiological investigation of the basis of the fMRI signal
TLDR
These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output, and that LFPs yield a better estimate of BOLD responses than the multi-unit responses.
Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging.
TLDR
These findings suggest that single-trial paradigms will be able to exploit the high temporal resolution of fMRI and provide experimental flexibility and time-resolved data for individual brain regions on a trial-by-trial basis.
The variability of human BOLD hemodynamic responses
“sparse” temporal sampling in auditory fMRI
TLDR
“sparse” temporal sampling is presented, using this technique, single volumes of brain images are acquired at the end of stimulus and baseline conditions, and the effective auditory stimulus for the activation is not masked by the scanner noise.
Functional magnetic resonance imaging
TLDR
The basic principles of MR Signal Generation, Signal, Noise, and Preprocessing of fMRI Data, and Ethical Issues in fMRI Research are outlined.
Laterality index in functional MRI: methodological issues☆
  • M. Seghier
  • Biology, Psychology
    Magnetic resonance imaging
  • 2008
Functional magnetic resonance imaging for neurosurgical planning in neurooncology
TLDR
The issues addressed are: stimulation paradigms, the influence of tumors on the blood oxygenation level-dependent (BOLD) signal, post-processing the fMRI time course, integration of f MRI results into neuronavigation systems, the accuracy of fMRI and (6) fMRI compared to intra-operative mapping (IOM).
Impact of fMRI Acoustic Noise on the Functional Anatomy of Visual Mental Imagery
TLDR
A nonadditive effect of fMRI gradient noise is demonstrated, resulting in a slight but significant effect on both performance and the neural activation pattern.
...
1
2
3
4
5
...