Pitfalls in TDM of antibiotic drugs: analytical and modelling issues.

  title={Pitfalls in TDM of antibiotic drugs: analytical and modelling issues.},
  author={Cees Neef and Dani{\"e}l J Touw and Anneke R Harteveld and Jaco Eerland and Donald R. A. Uges},
  journal={Therapeutic drug monitoring},
  volume={28 5},
The quality assurance program of the Dutch KKGT [Association for Quality Assessment in therapeutic drug monitoring (TDM) and Clinical Toxicology] has been running for more than 25 years. One of these programs concerns TDM of the antibiotic drugs gentamicin, tobramycin, amikacin, and vancomycin. We present two issues encountered in a recent survey. In a case of gentamicin monitoring and dose-adjustment, a systematic analytical error in some centers led to a dosing recommendation that differed… CONTINUE READING

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