Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia

  title={Pitavastatin calcium improves endothelial function and delays the progress of atherosclerosis in patients with hypercholesterolemia},
  author={Jing Zhao and Hui-min Yan and Ya Li and Jia Wang and Lu Han and Zhi-Hao Wang and Meng‐xiong Tang and Wei Zhang and Yun Zhang and Ming Zhong},
  journal={Journal of Zhejiang University-SCIENCE B},
BackgroundStatins have proven efficacy in inhibiting the onset and progress of atherosclerosis. The effectiveness of pitavastatin in reversing carotid atherosclerosis associated with hypercholesterolemia (HC) is unknown.ObjectivesTo explore the simultaneous effects of pitavastatin calcium on brachial arterial flow-mediated vasodilatation (FMD), carotid intima-media thickness (IMT), and arterial stiffness (β), three surrogate markers of atherosclerosis were studied in HC patients.MethodsA… Expand
Improvement of endothelial function by pitavastatin: a meta-analysis
A meta-analysis of all available clinical trials revealed a significant increase of FMD induced by pitavastatin, and the effect size was robust in the leave-one-out sensitivity analysis. Expand
The Effect of Atorvastatin + Aspirin on the Endothelial Function Differs with Age in Patients with HIV: A Case-Control Study.
A case-control study to assess which factors were associated with a reduction in the carotid intima-media thickness (IMT) and an increase in the brachial artery flow-mediated dilation (FMD) in HIV patients who received atorvastatin + aspirin during a period of 6 months. Expand
Pitavastatin attenuates atherosclerosis by suppressing NF-κB signaling in a high-cholesterol diet plus balloon catheter injury rabbit model.
The effect of pitavastatin on AS and nuclear factor-kappa-light-chain-enhancer of activated B cells (NF-κB) signaling in abdominal aortic ECs is evaluated and it is demonstrated that the anti-AS effect depends on restoring normal function of ECs and eliminating dysfunctional ECs by inducing apoptosis. Expand
Clinical benefits of pitavastatin: focus on patients with diabetes or at risk of developing diabetes.
It seems that pitavastatin should preferentially be considered in the treatment of dyslipidemia in diabetic patients or at risk of developing diabetes. Expand
Efeito da atorvastatina + aspirina versus placebo em pacientes com HIV em uso de antirretrovirais e com baixo risco cardiovascular na função endotelial e na inflamação: um ensaio clínico duplo cego e randomizado
Assessment of the efficacy of atorvastatin associated with acetylsalicylic acid (ASA) versus placebo in patients with HIV on antiretroviral therapy and with low cardiovascular risk in increasing flow-mediated dilatation of the brachial artery and to reduce carotid thickening, assessed by ultrasound. Expand
Celosins inhibit atherosclerosis in ApoE-/- mice and promote autophagy flow.
The therapeutic effect of CES on atherosclerosis may be related to the promotion of autophagy, and this study examined the therapeutic effects of celosins (CES), the active constituents extracted from Semen celosiae. Expand
Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases.
The cardioprotective effects of LXRs against atherosclerosis, myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, and myocardIAL hypertrophy are described and several potential research avenues are suggested. Expand
Extracellular Matrix Macromolecules as Potential Targets of Cardiovascular Pharmacotherapy.
The ECM of the cardiovascular tissue in health and disease as well as the effect of current cardiovascular drugs on the ECM are discussed in more detail and potential future pharmacotherapies targeting the ECm of the vasculature in various pathologies are presented. Expand
O Efeito da Atorvastatina + Aspirina na Função Endotelial Difere com a Idade em Pacientes com HIV: Um Estudo de Caso-Controle
Resumo Fundamento Pacientes com HIV têm maior probabilidade de apresentar doenças cardiovasculares quando comparados à população em geral. Objetivo Este foi um estudo de caso-controle que teve comoExpand
Hypolipidemiká a ich vplyv na funkciu endotelu: prehľad výsledkov klinických štúdií
Endotelova dysfunkcia spojena s funkcnou poruchou dilatacie ciev je jedno z prvých stadii aterosklerozy detekovateľných este pred vývinom morfologických cievnych zmien a predstavuje zavažnuExpand


The effect of pitavastatin calcium on endothelial dysfunction induced by hypercholesterolemia
Endothelial dysfunction induced by hypercholesteremia can be ameliorated by pitavastatin calcium treatment, which occurs in part through its antioxidative properties. Expand
Calcium Antagonist Lacidipine Slows Down Progression of Asymptomatic Carotid Atherosclerosis: Principal Results of the European Lacidipine Study on Atherosclerosis (ELSA), a Randomized, Double-Blind, Long-Term Trial
The greater efficacy of lacidipine on carotid IMT progression and number of plaques per patient, despite a smaller ambulatory blood pressure reduction, indicates an antiatherosclerotic action of lacIDipine independent of its antihypertensive action. Expand
Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease.
The present findings suggest that the impairment of FMD in the brachial artery, a marker of systemic endothelial function, is closely related to the angiographic extent of CAD. Expand
Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolemia (ASAP): a prospective, randomised, double-blind trial
The results show that aggressive LDL-cholesterol reduction by atorvastatin was accompanied by regression of carotid intima media thickness in patients with familial hypercholesterolaemia, whereas conventional LDL lowering was not. Expand
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Objectives. The relation between endotbelium-dependent vasodilator function in the brachial and coronary arteries was determined in the same subjects. Background. Coronary artery endothelialExpand
Arterial stiffness or endothelial dysfunction as a surrogate marker of vascular risk.
  • T. Anderson
  • Medicine
  • The Canadian journal of cardiology
  • 2006
The current paper reviews the various techniques available for the study of vascular health and finds that measures of endothelial health and arterial compliance provide important insights into the pathophysiology and treatment of atherosclerosis. Expand
Endothelial dysfunction, increased carotid artery intima-media thickness and pulse wave velocity, and increased level of inflammatory markers are associated with variant angina.
VA is associated with endothelial dysfunction and increased carotid IMT, brachial-ankle PWV, and inflammatory markers. Expand
Dilation and reduced distensibility of carotid artery in patients with abdominal aortic aneurysms.
Excessive arterial dilation and reduced distensibility without severe intimal disease were found in the carotid arteries of patients with AAA, suggesting that these patients may be subject to systemic arterial alterations, including structural and functional abnormalities. Expand
Distension of the Carotid Artery and Risk of Coronary Events: The Three-City Study
In the elderly, increased carotid distension was independently predictive of CHD, and this simple and noninvasive parameter might be of particular interest for cardiovascular risk assessment. Expand
Endothelial Dysfunction: A Marker of Atherosclerotic Risk
Given its reversibility and granted the availability of a diagnostic tool to identify patients at risk and to control the efficacy of therapy in clinical practice, endothelial dysfunction may be an attractive primary target in the effort to optimize individualized therapeutic strategies to reduce cardiovascular morbidity and mortality. Expand