Pit cells as liver-associated natural killer cells: morphology and function

  title={Pit cells as liver-associated natural killer cells: morphology and function},
  author={K. Nakatani and K. Kaneda and S. Seki and Y. Nakajima},
  journal={Medical Electron Microscopy},
  • K. Nakatani, K. Kaneda, +1 author Y. Nakajima
  • Published 2003
  • Medicine, Biology
  • Medical Electron Microscopy
  • Pit cells are one type of hepatic sinusoidal cells, defined morphologically as large granular lymphocytes (LGLs) and functionally as liver-associated natural killer (NK) cells. They are situated inside the sinusoidal lumen, adhering to the endothelial cells and Kupffer cells. They contain multivesicular body-related dense granules and rod-cored vesicles. The number and size of granules and vesicles differ between hepatic NK cells and peripheral blood cells, suggesting possible differentiation… CONTINUE READING
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    Publications referenced by this paper.
    Pit Cells as Liver-Associated Natural Killer Cells
    • 4
    On the cell biology of pit cells, the liver-specific NK cells.
    • 29
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    Liver-associated large granular lymphocytes: morphological and functional aspects.
    • 31
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    Origin and differentiation of hepatic natural killer cells (pit cells)
    • 40