Pit cells as liver-associated natural killer cells: morphology and function

@article{Nakatani2003PitCA,
  title={Pit cells as liver-associated natural killer cells: morphology and function},
  author={Kazuki Nakatani and Kenji Kaneda and Shuichi Seki and Yuji Nakajima},
  journal={Medical Electron Microscopy},
  year={2003},
  volume={37},
  pages={29-36}
}
Pit cells are one type of hepatic sinusoidal cells, defined morphologically as large granular lymphocytes (LGLs) and functionally as liver-associated natural killer (NK) cells. They are situated inside the sinusoidal lumen, adhering to the endothelial cells and Kupffer cells. They contain multivesicular body-related dense granules and rod-cored vesicles. The number and size of granules and vesicles differ between hepatic NK cells and peripheral blood cells, suggesting possible differentiation… CONTINUE READING