Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter.

@article{Gordon1997Pit1AG,
  title={Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter.},
  author={David Frederick Gordon and Suzanne R Lewis and B Haugen and Robert Andrew James and Michele T. McDermott and William Monford Wood and Eli Chester Ridgway},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 39},
  pages={
          24339-47
        }
}
The molecular determinants governing cell-specific expression of the thyrotropin (TSH) beta-subunit gene in pituitary thyrotropes are not well understood. The P1 region of the mouse TSHbeta promoter (-133 to -88) region interacts with Pit-1 and an additional 50-kDa factor at an adjacent site that resembles a consensus GATA binding site. Northern and Western blot assays demonstrated the presence of GATA-2 transcripts and protein in TtT-97 thyrotropic tumors. In electrophoretic mobility shift… CONTINUE READING
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