Pit-1 Positive α-Subunit Positive Nonfunctioning Human Pituitary Adenomas: A Dediferentiated GH Cell Lineage?

Abstract

Pit-1 is a transcription factor which has been reported to regulate differentiation toward GH,PRL and TSH in the anterior pituitary glands. In the human pituitary adenomas, Pit-1 is highly expressed in GH secreting and TSH secreting adenomas as it can well be anticipated. Interestingly, human non-functioning pituitary adenomas also express Pit-1, especially it was expressed in all aSU positive nonfunctioning adenomas. The human anterior pituitary cells are special in comparison with rodents in a finding that aSU is frequently colocalized with GH. As aSU is the first hormone appearing during fetal development in the rodent pituitary glands, it may be postulated that aSU Pit-1 positive cells undergo differentiation in the GH cell lineage. From this background, this paper proposes that “aSU positive Pit-1 Positive” cells are the ones in the GH cell lineage, more specifically a dedifferentiated cell lineage toward

DOI: 10.1023/A:1009954409469

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Cite this paper

@article{Osamura2004Pit1P, title={Pit-1 Positive α-Subunit Positive Nonfunctioning Human Pituitary Adenomas: A Dediferentiated GH Cell Lineage?}, author={Robert Yoshiyuki Osamura and Shigeyuki Tahara and Kimberly Komatsubara and Yuhta Itoh and Hiroko Kajiwara and Reiko Kurotani and Naoko Sanno and Akira Teramoto}, journal={Pituitary}, year={2004}, volume={1}, pages={269-271} }