Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage

@inproceedings{Ren2016PistolRA,
  title={Pistol ribozyme adopts a pseudoknot fold facilitating site-specific in-line cleavage},
  author={Aiming Ren and Nikola Vu{\vs}urovi{\'c} and Jennifer Gebetsberger and P. Gao and Michael Andreas Juen and Christoph Kreutz and Ronald Micura and Dinshaw J. Patel},
  booktitle={Nature chemical biology},
  year={2016}
}
The field of small self-cleaving nucleolytic ribozymes has been invigorated by the recent discovery of the twister, twister-sister, pistol and hatchet ribozymes. We report the crystal structure of a pistol ribozyme termed env25, which adopts a compact tertiary architecture stabilized by an embedded pseudoknot fold. The G-U cleavage site adopts a splayed-apart conformation with in-line alignment of the modeled 2'-O of G for attack on the adjacent to-be-cleaved P-O5' bond. Highly conserved… CONTINUE READING
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