Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch

@inproceedings{Patel2011PirtAT,
  title={Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch},
  author={Kush N. Patel and Qin Li Liu and Sonya N. Meeker and B J Undem and Xinzhong Dong},
  booktitle={PloS one},
  year={2011}
}
Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also… CONTINUE READING