Piroxicam-β-Cyclodextrin: A GI Safer Piroxicam

  title={Piroxicam-β-Cyclodextrin: A GI Safer Piroxicam},
  author={Carmelo Scarpignato},
  booktitle={Current medicinal chemistry},
Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartburn and abdominal discomfort to more serious events such as peptic ulcer with life-threatening complications of bleeding and perforation. The appreciation that CV risk is also increased further… CONTINUE READING