Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation

Abstract

Terminal differentiation of blood cells requires the concerted action of a series of transcription factors that are expressed at specific stages of maturation and function in a cell-type and dosage-dependent manner. Leukemogenic oncoproteins block differentiation by subverting the normal transcriptional status of hematopoietic precursor cells. Pirin (PIR… (More)
DOI: 10.1038/leu.2009.247

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@article{Licciulli2010PirinDI, title={Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation}, author={Silvia Licciulli and Valeria Cambiaghi and Gaia Scafetta and Alicja M. Gruszka and Myriam Alcalay}, journal={Leukemia}, year={2010}, volume={24}, pages={429-437} }