Piribedil for restless legs syndrome: A pilot study

@article{Evidente2001PiribedilFR,
  title={Piribedil for restless legs syndrome: A pilot study},
  author={Virgilio Gerald H Evidente},
  journal={Movement Disorders},
  year={2001},
  volume={16}
}
  • V. Evidente
  • Published 1 May 2001
  • Medicine, Psychology
  • Movement Disorders
Thirteen consecutive patients with restless legs syndrome (RLS) were treated with piribedil and were rated using an RLS rating scale (0–10) and subjective response (0–100%); 11/13 (85%) had improvement of their mean RLS scores with subjective response ranging from 30% to 100% (mean 74.6%). This pilot study suggests that piribedil is effective for RLS. 
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TLDR
Preliminary results suggest that several non-pharmacological therapies should be promising as alternatives or adjuvants to drug treatments and dopamine agonists, gabapentin and pregabalin should be considered as first-line therapies.
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  • 2002
TLDR
The present review attempts to explain current strategies of treatment for restless legs syndrome in relation to aetiological, genetic and pathophysiological findings.
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TLDR
It was shown that, for example, pergolide, ropinirole, pramipexole and cabergoline alleviated RLS symptoms in 70–90% of patients and a new non-oral (transdermal) formulation of one dopamine receptor agonist, rotigotine, has recently been developed and shown to be efficacious in RLS.
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Evidence-based and clinical guidelines identify dopamine agonists as a first-line treatment for daily restless legs symptoms, and such substances are in the process of registration for this indication.
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