Corpus ID: 10000419

Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy.

  title={Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy.},
  author={T. Shimizu and M. Fukagawa and T. Kuroda and S. Hata and Y. Iwasaki and M. Nemoto and K. Shirai and S. Yamauchi and S. Margolin and F. Shimizu and K. Kurokawa},
  journal={Kidney international. Supplement},
Pirfenidone (PFD) is a new compound that prevents and even reverses the extracellular matrix accumulation in several organs as shown by experimental and clinical studies. In the present study, we examined the effect of PFD (500 mg/kg daily in the food) on the progression of chronic renal failure (CRF) in the 5/6 nephrectomy rat model. Proteinuria progressively increased in rats with renal ablation (C) at 12 weeks. Urinary protein excretion in PFD-treated rats (P) was numerically lower than C… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of this study is to determine whether a new investigational drug, pirfenidone, will be an effective therapy for diabetic patients with kidney dysfunction. Our hypothesis is… Expand
ConditionsDiabetes Mellitus, Diabetic Nephropathy
Renoprotective properties of pirfenidone in subtotally nephrectomized rats.
Halofuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats.
Antifibrotic Effects of Pirfenidone in Rat Proximal Tubular Epithelial Cells
Pirfenidone is renoprotective in diabetic kidney disease.
Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats.
Pirfenidone suppressed the development of glomerulosclerosis in the FGS/Kist mouse.