Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells

@inproceedings{Hisatomi2012PirfenidoneIT,
  title={Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells},
  author={Keiko Hisatomi and Hiroshi Mukae and Noriho Sakamoto and Yuji Ishimatsu and Tomoyuki Kakugawa and Shintaro Hara and Hanako Fujita and Seiko Nakamichi and Hisashi Oku and Yoshishige Urata and Hiroshi Kubota and Kazuhiro Nagata and Shigeru Kohno},
  booktitle={BMC pulmonary medicine},
  year={2012}
}
BACKGROUND Pirfenidone is a novel anti-fibrotic and anti-inflammatory agent that inhibits the progression of fibrosis in animal models and in patients with idiopathic pulmonary fibrosis (IPF). We previously showed that pirfenidone inhibits the over-expression of collagen type I and of heat shock protein (HSP) 47, a collagen-specific molecular chaperone, in human lung fibroblasts stimulated with transforming growth factor (TGF)-β1 in vitro. The increased numbers of HSP47-positive type II… CONTINUE READING