Pirfenidone Inhibits Lung Allograft Fibrosis through L‐Arginine–Arginase Pathway

  title={Pirfenidone Inhibits Lung Allograft Fibrosis through L‐Arginine–Arginase Pathway},
  author={Hanzhong Liu and Peter A. Drew and Andrew C. Gaugler and Yanping Cheng and Gary A Visner},
  journal={American Journal of Transplantation},
Transplant‐related lung fibrosis is characterized by excessive fibro‐collagenous deposition. Induction of arginase, an enzyme that metabolizes L‐arginine to urea and L‐ornithine, is vital for collagen synthesis. Pirfenidone is an investigational anti‐fibrotic agent shown to be effective in blocking pulmonary fibrosis. The purpose of this study was to determine if pirfenidone was protective against the development of fibro‐collagenous injury in rat lung orthotopic transplants through altering L… 

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