Piracetam prevents pentylenetetrazol kindling-induced neuronal loss and learning deficits

@article{Pohle1997PiracetamPP,
  title={Piracetam prevents pentylenetetrazol kindling-induced neuronal loss and learning deficits},
  author={W. R. von Pohle and Axel Becker and Gisela Grecksch and A. Juhre and A. Willenberg},
  journal={Seizure},
  year={1997},
  volume={6},
  pages={467-474}
}
The effect of the nootropic drug piracetam (100 mg/kg) on kindled seizures, kindling-induced learning deficits, and histological alterations due to changes in central excitability was investigated in Wistar rats. The animals were kindled by repeated i.p. injections of an initially subconvulsive dose of pentylenetetrazol (PTZ). As a control, piracetam or physiological saline was given 60 minutes before PTZ. Twenty-four hours after completion of kindling the rats were tested in a shuttle-box… CONTINUE READING

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gliosides improve a memory deficit in pentylenetetrazol - kindled rats

G.. Becker Grecksch, A., C. Gadau
Pharmacology , Biochemistry and Behoviour • 1995

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