Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice.

  title={Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice.},
  author={F. Felipe and Juc{\'e}lio Trajano Sousa Filho and Louise Emanuele de Oliveira Souza and Jefferson Alexandre Silveira and D. E. Uch{\^o}a and E. Silveira and O. D. L. Pessoa and G. Viana},
  • F. Felipe, Jucélio Trajano Sousa Filho, +5 authors G. Viana
  • Published 2007
  • Chemistry
  • Phytomedicine
  • In the present work, we studied the effects of piplartine (PIP), an amide alkaloid isolated from the roots of Piper tuberculatum (Piperaceae), in the elevated plus maze, open field, rota rod, pentylenetetrazole (PTZ)-induced seizures, and forced swimming tests, in mice (Swiss, male, 25 g) to assess anxiolytic, sedative, muscle relaxant, anticonvulsant and antidepressant effects, respectively. Results showed that PIP (50 and 100 mg/kg, i.p.), similarly to diazepam, significantly increased not… CONTINUE READING
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