Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.

@article{Kim2014PiperlongumineTI,
  title={Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.},
  author={Tae Hyong Kim and Jieun Song and Sung Hak Kim and Arav Krishnavadan Parikh and Xiaokui Mo and Kamalakannan Palanichamy and B. Devinder Kaur and Jianhua Yu and Sung Ok Yoon and Ichiro Nakano and C K Kwon},
  journal={Neuro-oncology},
  year={2014},
  volume={16 10},
  pages={1354-64}
}
BACKGROUNDS Piperlongumine, a natural plant product, kills multiple cancer types with little effect on normal cells. Piperlongumine raises intracellular levels of reactive oxygen species (ROS), a phenomenon that may underlie the cancer-cell killing. Although these findings suggest that piperlongumine could be useful for treating cancers, the mechanism by which the drug selectively kills cancer cells remains unknown. METHODS We treated multiple high-grade glioma (HGG) sphere cultures with… CONTINUE READING
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