Piperine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in BV2 microglia.

Piperine, the chief alkaloid isolated from Piper nigrum, has been known to have anti-inflammatory effect. However, the effects of piperine on neuroinflammation have not been reported. In the present study, we evaluated the effects of piperine on neuroinflammation in BV2 microglia and investigated the molecular mechanism. The results showed that piperine… CONTINUE READING