Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.

@article{Khan2006PiperineAP,
  title={Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus.},
  author={Inshad Ali Khan and Zahid Mehmood Mirza and Ashwani Kumar and Vijeshwar Verma and Ghulam Nabi Qazi},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 2},
  pages={810-2}
}
Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps. 

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Piperine, an alkaloid derived from black pepper, increases serum response of beta-carotene during 14 days of oral beta-carotene supplementation

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