Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4

  title={Piperine, a Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4},
  author={Rajinder Kumar Bhardwaj and Hartmut Glaeser and Laurent Becquemont and Ulrich Klotz and Suresh Kumar Gupta and Martin F. Fromm},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={645 - 650}
Dietary constituents (e.g., in grapefruit juice; NaCl) and phytochemicals (e.g., St. John's wort) are important agents modifying drug metabolism and transport and thereby contribute to interindividual variability in drug disposition. Most of these drug-food interactions are due to induction or inhibition of P-glycoprotein and/or CYP3A4. Preliminary data indicate that piperine, a major component of black pepper, inhibits drug-metabolizing enzymes in rodents and increases plasma concentrations of… 

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